| Home | E-Submission | Sitemap | Contact Us
top_img
REVIEW ARTICLE
Thrombolysis in massive pulmonary embolism
Seung-Ick Cha
Kyungpook National University Hospital, Daegu, Korea
Corresponding Author: Seung-Ick Cha ,Tel: 82-53-200-6412, Fax: 82-53-426-2046, Email: sicha@knu.ac.kr
Received: December 15, 2016;  Accepted: March 28, 2017.
Share :  
ABSTRACT
Massive pulmonary embolism (PE) is defined as sustained hypotension, not due to a cause other than PE, pulselessness, or persistent profound bradycardia. Therefore, although PE exhibits variable clinical course, massive PE is a life-threatening condition of which in-hospital reaches over 15% and which consequently requires thrombolysis as well as anticoagulation. According to recent guidelines of PE, systemic thrombolysis is recommended over no such therapy in patients with massive PE who do not have a high bleeding risk. Currently, continuous infusion of alteplase over 2 hours plus anticoagulation using unfractionated heparin constitutes a standard regimen. When systemic thrombolysis is failed or contraindicated, patients with massive PE can undergo surgical embolectomy or catheter-directed thrombolysis, if specialist services and expertise are available. In addition, hemodynamic and respiratory supports, including extracorporeal membrane oxygenation, are needed for successful treatment of massive PE.
Keywords: hypotension; pulmonary embolism; tissue plasminogen activator
TOOLS
PDF Links  PDF Links
Full text via DOI  Full text via DOI
Download Citation  Download Citation
Supplement  Supplement
  E-Mail
Share:      
METRICS
0
Crossref
120
View
0
Download
Thrombolysis in Massive Pulmonary Embolism  2017 May;3(1)
Editorial Office
95, Dunsanseo-ro, Seo-gu, Daejeon, 35233, Korea
TEL : +82-42-484-2426   FAX : +82-42-484-2429   E-mail : ksth@thrombo.or.kr

About |  Browse Articles |  Current Issue |  For Authors and Reviewers
Copyright© Korean Society on Thrombosis and Hemostasis. All rights reserved.              Powerd by M2community